Our Science
OMNIA asks how the properties of a nanoparticle interact
with the biological features of a tumour to shape its distribution,
cellular uptake and effects. Our approach connects the design of materials
with detailed measurements of the tissues in which they act.
Nanoparticles with comparable properties
We will investigate lipid nanoparticles, gold nanoparticles, carbon dots, graphene oxide and MXenes. Shared characterisation methods will help us compare properties such as size, surface chemistry, stability and targeting features, and relate these properties to biological behaviour.
Cancer models that capture biological context
Three-dimensional spheroids, organoids and co-cultures will allow us to investigate nanoparticle interactions within more complex cellular environments. Preclinical studies will extend this work to tumour responses, distribution across organs and safety. The programme includes models of glioblastoma, triple-negative breast cancer, melanoma and malignant pleural mesothelioma.
Spatial multi-omics and single-cell analysis
Spatial approaches measure molecular features while retaining their location within a tissue. OMNIA will combine information on gene expression, proteins and metabolites with imaging and single-cell profiling to examine nanoparticle-associated responses in cancer, immune and supporting cells.
Interpretable AI and data integration
The project will bring together data on material properties, imaging, molecular profiles and biological responses. AI-based analysis will help identify patterns across these measurements and generate testable explanations for how particular nanoparticle designs behave in different biological settings.
Connecting the evidence
Nanoparticle design and characterisation
inform experiments in three-dimensional and preclinical models. Spatial and
single-cell measurements reveal where interactions occur and which biological programmes are affected. Integrated analysis then guides the selection of material features and strategies for further testing.
Responsible and reproducible research
Shared protocols, quality checks and clear
data documentation will support comparison across laboratories.
Ethical review, responsible data handling and consideration of future regulatory requirementsare integrated into the programme.
Work Packages
Coordination, Ethics and Management
Lead: Ankara University
Coordinate the research programme, project
governance, ethics, quality assurance and data stewardship.
Nanomedicine Design, Characterization and Regulatory Strategies
Lead: Bluepharma
Develop and characterise the nanoparticle panel, define shared quality criteria and consider stability, scalability and regulatory pathways.
In vitro 3D models, spatial multi-omics, and integrative analysis
Lead: University of Birmingham
Study nanoparticle interactions in
three-dimensional cancer models and combine spatial, single-cell and computational analyses.
In vivo orthotopic models, multi-organ spatial profiling, and integrative analysis
Lead: Ankara University
Investigate nanoparticle distribution, biological activity and safety in preclinical models and across organs.
Knowledge Transfer / Training
Lead: University of Latvia
Coordinate knowledge exchange and the
development of shared research capabilities across the consortium.
Dissemination, Translation, and Exploitation
Lead: YourScienceBE
Communicate the project, support the use of its findings and methods, and develop pathways for their longer-term uptake.
OMNIA
Connecting nanomedicine, spatial biology & AI.
Europen research. Global connections.
Quick Links
Legal
Privacy
Terms
Cookies
Site
EU Funding Acknowledgement
OMNIA is funded by the European Union under the Horizon Europe Marie Skłodowska-Curie Actions Staff Exchanges programme, Grant Agreement No. 101299913.
Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Executive Agency (REA). Neither the European Union nor the granting authority can be held responsible for them.
© 2026 OMNIA Project All